Impaired Behavioral Responses to Noxious Heat in V1V3dKO mice.

<p>(A) Latency to paw withdrawal in the hot plate test of WT and V1V3dKO mice (n = 15 WT, n = 12 knockouts) (left), WT and TRPV1-KO mice (n = 21 WT, n = 12 KO) (middle), WT and TRPV3-KO mice (n = 21 WT, n = 9 KO) (right). (B) Latency to tail withdrawal in the tail immersion test of WT and V1V3dKO mice (n = 15 WT, n = 12 KO) (left), WT and TRPV1-KO mice (n = 21 WT, n = 11 KO) (middle), and WT and TRPV3-KO mice (n = 21 WT, n = 9 KO) (right). (C) Latency to paw withdrawal of WT and V1V3dKO mice (n = 11 WT, n = 11 KO) in the Hargreaves test before (base line) and 24 hours, 3 days and 7 days after intraplantar injection of CFA. (D) 50% paw withdrawal threshold (g) of WT and V1V3dKO mice (n = 9 WT, n = 7 KO) in the Von Frey test using the up and down method, before (base line) and 24 hours, 3 days and 7 days after intraplantar injection of CFA. *p<0.05; **p<0.01; ***p<0.001. Data shown represent mean ± <i>sem</i>., CFA, Complete Freund's Adjuvant.