Effect of MC1R functionality on CFA-induced thermal hyperalgesia and mechanical allodynia.

<p>Data represents the paw withdrawal latency [<b>A</b>], paw withdrawal threshold [<b>B</b>] as measures of thermal hyperalgesia and mechanical allodynia prior to and post-injection of CFA (n = 4–5 per genotype), shown as mean responses ± SEM. Differences in behaviours prior to injection were observed in female <i>Mc1r^e</i> mice only, when compared to their control littermates, Tg-<i>Mc1r^e</i> in [<b>A</b>] paw withdrawal latency (††P<0.01). CFA-induced increased ipsilateral sensitivity (IPSI; injured hindlimb) compared to contralateral (CON; un-injured hindlimb) are shown (*P<0.05). Female <i>Mc1r^e</i> mice were found to have a significantly higher ipsilateral thresholds when compared to their control littermates, Tg-<i>Mc1r^e</i> ipsilateral thresholds in [<b>A</b>] paw withdrawal latency and [<b>B</b>] paw withdrawal threshold at 0.5–2 hours post-injection (¶P<0.05).