Nav1.7 KOs do not develop CFA-induced thermal hyperalgesia.

<p>Latency time to withdrawal from radiant heat stimulus for Nav1.7 KO (n = 4) and WT/HET littermates (n = 9) at baseline and 1, 3, and 7 days following CFA injection. WT/HET mice developed robust hyperalgesia in the affected paw 24 hours post-CFA injection that returned to baseline at day 7. KO mice did not develop hyperalgesia. Differences between KO and WT/HET were statistically significant at baseline (WT/HET = 11.5 sec ±0.8 sec; KO = 16 sec ±0.8 sec, p = 0.0001), day 1 (WT/HET = 4.0 sec ±0.5 sec, KO = 15.7 sec ±0.9 sec, p<0.0001) and day 3 (WT/HET = 9.6 sec ±1.0 sec, KO = 17.8 sec ±0.7 sec, p = 0.0028), but not at day 7 (WT/HET = 11.3 sec ±1.1 sec, KO = 15.3 sec ±1.0 sec, p = 0.5381), at which time control animals had recovered back to baseline (all values mean ± S.E.M, ANOVA).