Behavioural responses to acute mechanical or noxious thermal stimuli in naïve animals.

<p>Adult male and female <i>Mc1r^e</i> and their littermate controls Tg-<i>Mc1r^e</i>, or <i>A^y-Jkn1</i> and their littermate control non-<i>A^y-Jkn1</i> mice were assessed for responses to acute noxious thermal or non-noxious mechanical stimuli. The paw withdrawal latency (PWL; n = 8–11 per genotype) [<b>A</b>], paw withdrawal threshold (PWT; n = 8–11 per genotype) [<b>B</b>] as measures of thermal hyperalgesia and mechanical allodynia respectively of both hind-paws (right and left hind-paw responses combined) in naïve animals are shown as mean responses ± SEM. Significant differences between <i>Mc1r^e</i> and <i>A^y-Jkn1</i> and their respective controls were only seen in female <i>Mc1r^e</i> mice in [<b>A</b>] paw withdrawal latency (***P<0.01).