Model based parameter estimation.

<p><b>A</b>: Best fit of the model predictions (lines) to experimentally determined cell fractions after BrdU pulse labelling (dots). U87: In vitro cultured U87 human glioblastoma cancer cell line (three replicates). V79: In vitro cultured V79 Chinese hamster cells (single replicate) (courtesy G. Wilson). Best fit parameter values used to compute model predictions (U87: V79: units are hours). <b>B</b>: Approximate ML regions for the parameters and associated to each phase (gray: red: green: ). <b>C</b>: Bayesian bi-variate 99%-credibility regions for the parameters and for each phase. Arrows indicate point estimates and the dashed lines delineate the information that could have been gained in our <i>thought</i> experiment under noise-free conditions from two support points, one at and a second at . The U87 data set was generated as described in the Experimental Methods section. The V79 data set was a kind gift of G. Wilson.