Model output.

<p>(A) The model estimates the time evolution of each one of the cell subpopulations considered, fully differentiated cells (D; blue line); progenitor cells (P; red line); and cancer stem cells (CSC; green line). (B) by plotting the cell fractions for each cell population (D/N; blue line), (P/N; red line), and (CSC/N; green line), it is possible to search for feasible and biologically consistent solutions (i.e. d[CSC/N]/dt = 0; C/N<0.01). (C) Only a relatively small set of parameter combinations result in solutions that satisfy the constraint d[CSC/N]/dt = 0. The solution defined by the vector Φ_i/j = [1.0, 0.01, 5.35, 0.8, 0.01, 0.1, 1.0] satisfy d[CSC/N]/dt = 0 only if when the specific value of Φ_4/1 = 5.35 was used (green line). Values of Φ_4/1 = <i>k₄</i>/<i>k₁</i>>3.5 (purple and light blue line) cause d[CSC/N]/dt<0; and values of Φ_4/1 = <i>k₄</i>/<i>k₁</i><3.5 (red and dark blue line) cause d[CSC/N]/dt>0.