The fcyton cell proliferation model.

<p>(A) A graphical representation summarizing the model parameters required to calculate the total number of cells in each generation as a function of time. Division and death times are assumed to be log-normally distributed and different between undivided and dividing cells. Progressor fractions (Fs) determine the fraction of responding cells in each generation committed to division and protected from death. (B,C) Analysis of the accuracy associated with fitting fcyton parameters for a set of 1,000 generated realistic datasets of generational cell counts assuming perfect cell counts and an optimized <i>ad hoc</i> objective function (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067620#pone.0067620.s012" target="_blank">Text S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067620#pone.0067620.s010" target="_blank">Tables S3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067620#pone.0067620.s011" target="_blank">S4</a>). (B) Average percent error in generational cell counts normalized to the maximum generational cell count for each time course. Numbers indicate an error ≥ 0.5%. (C) Analysis of the error associated with determining key fcyton parameters. Box plots represent 5, 25, 50, 75, and 95 percentile values. Outliers are not shown. For analysis of all fcyton parameter errors see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0067620#pone.0067620.s002" target="_blank">Figure S2</a> (green).