A) Tumor growth curves, cancer stem cell (CSC) number and fraction as a function of time for tumors without evolution (control, green solid curve) and with evolution probability of 50% (p_mut = 0.5, red dashed curve).

<p><b>B)</b> Simulation snapshots of the smallest, an average-sized and biggest tumor in the control and evolved tumor at t = 730 days. s: number of cancer stem cells; n: number of total cancer cells. <b>C)</b> Temporal evolution of the 28 phenotypes in the smallest evolved tumor and trait details of the 10 most common phenotypes. <b>D)</b> Temporal evolution of the 1000 most common phenotypes at t = 730 days in an evolved averaged-sized tumor and trait details of the 10 most common phenotypes. <b>E)</b> Temporal evolution of the 1000 most common phenotypes at t = 730 days in the biggest evolved tumor and trait details of the 10 most common phenotypes.