Strategy for model calibration and validation.
- Hermann B. Frieboes (383421)
- Bryan R. Smith (396281)
- Zhihui Wang (88248)
- Masakatsu Kotsuma (752663)
- Ken Ito (396283)
- Armin Day (752664)
- Benjamin Cahill (752665)
- Colin Flinders (752666)
- Shannon M. Mumenthaler (752667)
- Parag Mallick (2077)
- Eman Simbawa (752668)
- A. S. AL-Fhaid (752669)
- S. R. Mahmoud (752670)
- Sanjiv S. Gambhir (163568)
- Vittorio Cristini (383423)
Publication date
June 2015
DOIAbstract
<p>Values for mathematical model input parameters are initially calibrated from experimental data obtained from untreated subjects and cell culture, yielding blood volume fraction, diffusion penetration distance, radius of blood sources, and fraction of cells killed in culture. Based on these parameter values, the model then calculates the fraction of tumor volume that would be killed <i>in vivo</i>, which can be compared to experimental data obtained from treated subjects.</p
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