Analysis of simulated dual pulse labelling data.

<p><b>A</b>: Average kinetics of unlabelled (dashed line) and labelled cell cohorts (colored lines) were computed from Eq. 25, using ML parameter estimates from the U87 and the V79 data sets (U87: V79: units are hours). Support points and repeats were chosen according to the real experiments. Multinomial noise was added, mimicking the residuals found in the original data sets (see the Computational Methods section for more details). Finally, model solutions (lines) were fitted to the synthetic data sets (triangles). Best fit parameters (U87: V79: units are hours) <b>B</b>: ML parameter estimates from simulated data. All ML regions converge to point estimates (arrows). Squares indicate parameters used for generating the data (see A). <b>C</b>: Bayesian bi-variate 99%-credibility regions for the parameters and for each phase, based on the artificial data.