HIF-1β-silencing suppresses tumor cell invasiveness and migration ability.
- Sung Hoon Choi (605545)
- Ae Ri Chung (605546)
- Wonseok Kang (139862)
- Jun Yong Park (131968)
- Mi Sol Lee (605547)
- Shin Won Hwang (605548)
- Do Young Kim (131974)
- Seung Up Kim (131988)
- Sang Hoon Ahn (131984)
- Seungtaek Kim (89665)
- Kwang-Hyub Han (131978)
Publication date
July 2014
DOIAbstract
<p>(A) Compared to control, invasiveness of tumor cell was significantly reduced in Hep3B cells transfected with siHIF-1α or <b>-</b>1β as demonstrated by transwell assays. (B) As compared to control, markedly reduced migration of HIF-1α- or <b>-</b>1β-silenced Huh-7 cells was confirmed by scratch and wound healing assay. NT, non-target; siGFP, siRNA against green fluorescent protein; siHIF1-α, siRNA against HIF-1α; siHIF-1β, siRNA against HIF-1β.</p
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