Ad/VNA-BoNTA treatment provides long term protection from botulism in mice- study 1.

<p>Groups of five mice (80 mice in total) were treated with 3×10¹⁰ vp of Ad/VNA-BoNTA or Ad/VNA-control on day 0 and one group treated with each of the two Ad/VNAs were administered 10 LD₅₀ of BoNT/A1 at the various times post-treatment. Black bars indicate % survival of mice treated with Ad/VNA-BoNTA and later intoxicated at the indicated times. White bars indicate % survival of mice treated with Ad/VNA-control. Groups with no survival show a short bar ending at 0. An asterisk indicates a significant difference (p<0.05) from the control group.