<p>Groups of five mice (60 mice in total) were treated and challenged as for study 1 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106422#pone-0106422-g002" target="_blank">Figure 2</a>) although the timeframe was extended to four months. Black bars indicate % survival of mice treated with Ad/VNA-BoNTA and later intoxicated at the indicated times. White bars indicate % survival of mice treated with Ad/VNA-control. Groups with no survival show a short bar ending at 0. An asterisk indicates a significant difference (p<0.05) from the control group.</p
<p>Antibodies and FP:mAb complexes were tested for their ability to ...
<p>A 10 LD<sub>50</sub> dose of toxin was administered by intraperitoneal injection either 1.5 or 3 ...
<p>BoNT/A (10 LD50) was administered via intra-peritoneal injection to Swiss ...
<p>Groups of five mice (80 mice in total) were treated with 3×10<sup>10</sup> vp of Ad/VNA-BoNTA or ...
<p>A 10 LD<sub>50</sub> dose of BoNT/A1 was administered by intraperitoneal injection to groups of f...
<p>Mice were treated with Ad/VNA-BoNTA and intoxicated as in study 1. Here, mice were bled one week ...
Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as bo...
<p>Serum from mice treated with Ad/VNA-BoNTA or Ad/VNA-control was collected monthly from weeks 2 th...
Current therapies for most acute toxin exposures are limited to administration of polyclonal antitox...
Current therapies for most acute toxin exposures are limited to administration of polyclonal antitox...
<p>Symptoms of intoxication and time to death were monitored following administration of the indicat...
<p>Protection of mice from BoNT/B lethality by administration of a double-tagged heterodimer of anti...
<p>Groups of five mice (10 mice in total) were treated with 3×10<sup>10</sup> vp of Ad/VNA-BoNTA (<b...
<p>Symptoms of BoNT/A intoxication and lethality were monitored following administration of single- ...
Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin...
<p>Antibodies and FP:mAb complexes were tested for their ability to ...
<p>A 10 LD<sub>50</sub> dose of toxin was administered by intraperitoneal injection either 1.5 or 3 ...
<p>BoNT/A (10 LD50) was administered via intra-peritoneal injection to Swiss ...
<p>Groups of five mice (80 mice in total) were treated with 3×10<sup>10</sup> vp of Ad/VNA-BoNTA or ...
<p>A 10 LD<sub>50</sub> dose of BoNT/A1 was administered by intraperitoneal injection to groups of f...
<p>Mice were treated with Ad/VNA-BoNTA and intoxicated as in study 1. Here, mice were bled one week ...
Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as bo...
<p>Serum from mice treated with Ad/VNA-BoNTA or Ad/VNA-control was collected monthly from weeks 2 th...
Current therapies for most acute toxin exposures are limited to administration of polyclonal antitox...
Current therapies for most acute toxin exposures are limited to administration of polyclonal antitox...
<p>Symptoms of intoxication and time to death were monitored following administration of the indicat...
<p>Protection of mice from BoNT/B lethality by administration of a double-tagged heterodimer of anti...
<p>Groups of five mice (10 mice in total) were treated with 3×10<sup>10</sup> vp of Ad/VNA-BoNTA (<b...
<p>Symptoms of BoNT/A intoxication and lethality were monitored following administration of single- ...
Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin...
<p>Antibodies and FP:mAb complexes were tested for their ability to ...
<p>A 10 LD<sub>50</sub> dose of toxin was administered by intraperitoneal injection either 1.5 or 3 ...
<p>BoNT/A (10 LD50) was administered via intra-peritoneal injection to Swiss ...