Serum levels of VNA-BoNTA following Ad/VNA-BoNTA treatments- study 2.

<p>Mice were treated with Ad/VNA-BoNTA and intoxicated as in study 1. Here, mice were bled one week prior to intoxication and survivors were also bled one week post-intoxication. VNA-BoNTA serum levels were quantified as described in Methods and Materials. The VNA concentration (ng/ml) from a single mouse serum is represented as a black dot. Lines connecting two dots show repeated measurements (pre- and post- intoxication) from surviving mice in the final two groups. The two circles indicate the VNA levels from the three mice that did not survive BoNT/A1 intoxication. Dots within the shaded area represent VNA serum levels below detection.