Mechanical hypersensitivity induced by intraplantar injection of 0.001% capsaicin (CAP) or 5 µg CGRP.

<p>(A, B) Force-response curves for the ipsilateral hindpaw after injection of CAP or vehicle (VEH) in <i>Nf1^+/−</i> (circles) or WT (squares) mice. Data are the mean ± SEM of responses by 5–7 mice of each gender and genotype. (C, D) Force-response curves for the ipsilateral hindpaw after injection of CGRP or PBS in <i>Nf1^+/−</i> (circles) or WT (squares) mice. Data in panels C-D are the mean ± SEM of responses by 4–8 mice of each gender and genotype, with the exception of CGRP in <i>Nf1^+/−</i> mice where 11 mice were tested.