Hot-plate test of thermal analgesia.

<p>Hot-plate analgesia testing of vehicle- and capsaicin-treated mice was performed at 4, 8, and 12 weeks of age to verify decreased peripheral sensory nerve function prior to tibial compression. Capsaicin-treated mice exhibited significantly longer latency times than vehicle-treated mice at all time points when exposed to a constant 55°C thermal stimulus, indicating decreased thermal sensitivity. * indicates significant differences between capsaicin- and vehicle-treated mice (p < 0.05).