Targeting TRPV1 and ERK signaling pathway attenuated mechanical hyperalgesia by von Frey filaments.

<p>(A) Mechanical responses of FM mice. (B) Mechanical responses of Trpv1^-/- mice. (C) Mechanical responses of FM mice pretreated with CZP. (D) Mechanical responses of FM mice pretreated with U0126. Mice were tested before injection (baseline, B), 4 hours after injection, day 1 (D1), day 5 (D5), day 6 (D6), and day 8 (D8). Red arrowheads indicate acid injection. **<i>p</i> < 0.01 compared to baseline. (n = 6 mice per group).