Role of MyD88 and TRIF signalling pathways in LPS-induced mechanical inflammatory hyperalgesia in the mice paw.
- Igor L. Calil (530000)
- Ana C. Zarpelon (530001)
- Ana T. G. Guerrero (530002)
- Jose C. Alves-Filho (530003)
- Sergio H. Ferreira (530004)
- Fernando Q. Cunha (276880)
- Thiago M. Cunha (276874)
- Waldiceu A. Verri Jr (530005)
Publication date
March 2014
DOIAbstract
<p>(A) MyD88<sup>+/+</sup> (C57BL/6 background) and MyD88<sup>-/-</sup> (C57BL/6 background) mice received i.pl. injection of LPS (100 ng/paw) or saline. (B) TRIF<sup>+/+</sup> (129Sv background) and TRIF<sup>-/-</sup> (129Sv background) mice received i.pl. injection of LPS (100 ng/paw) or saline. Mechanical hyperalgesia was evaluated 3 h after LPS injection. *<i>P</i><0.05 compared with saline control, #<i>P</i><0.05 compared with MyD88<sup>+/+</sup> or TRIF<sup>+/+</sup> mice injected with LPS. One-way ANOVA followed by Tukey's t test.</p
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