Cluster 1, highly expressed miRNAs during osteoclastogenesis.

<p>(A) miRNA expression heat map. The dendrogram shows the similarities between the expression profiles of the significantly changed miRNAs. Down-regulated miRNAs are indicated by the “*” symbol. Blue represents low expression, red high expression, and yellow intermediate expression. Please note that, for this cluster only, the color balance of the expression heat map and its key have been altered (compared to the original Cluster 1 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107262#pone.0107262.s001" target="_blank">Figure S1</a>), to better illustrate the changes in expression with time of differentiation. (B) Up-regulated miRNAs and predicted pathways heat map. Red color indicates lower p values (more significant), and higher interaction of each miRNA with a specific molecular pathway. (C) Down-regulated miRNAs and predicted pathway heat map. Significant miRNA-pathway interaction p<0.001.