Left ventricular dilatation, hypertrophy, and fibrosis is prominent in α-MHC CaMKKβ^kd TG mice compared with WT mice after TAC.

<p>A. Low-power magnifications of Masson Trichrome stained images of the left ventricle of WT and α-MHC CaMKKβ^kd TG mice with or without TAC. B. Heart weight (HW) and lung weight (LW) of WT and α-MHC CaMKKβ^kd TG mice with or without TAC. Each value was normalized to tibial length (TL). Values are the means ± S.E. of 5 mice (*p<0.05 vs sham control, †p<0.05 vs WT after TAC). C. Relative expression levels of hypertrophy-associated genes in WT and α-MHC CaMKKβ^kd TG mice with or without TAC. Values are the means ± S.E. of four mice (*p<0.05 vs sham control, †p<0.05 vs WT after TAC). D. Picrosirius staining of the left ventricle in WT and α-MHC CaMKKβ^kd TG mice with or without TAC and measurement the area of fibrosis. Values are the means ± S.E. of three to five mice (*p<0.05 vs sham control, †p<0.05 vs WT after TAC).