Kaplan-Meier plot of cardiac failure-free fraction and cardiac function of WT and α-MHC CaMKKβ^kd TG mice after TAC.

<p>A. α-MHC CaMKKβ^kd TG mice had a lower cardiac failure-free fraction compared with WT mice. Log-rank test indicates the significant difference between WT and α-MHC CaMKKβ^kd TG mice after TAC (p = 0.0002) (WT; n = 26, TG; n = 25). B. Representative echocardiograph pictures of WT and α-MHC CaMKKβ^kd TG hearts 3 weeks after TAC. Arrows indicate left ventricular cavities of diastolic and systolic phase. C. Serial changes in echocardiographic parameters of WT and α-MHC CaMKKβ^kd TG mice after TAC. *p<0.05 vs WT (n = 3–5 for each group).