MACF1 deletion exacerbates pressure overload induced hypertrophy.

<p>3 weeks after control or TAC conditions, WT or MACF1 KO hearts were collected and used to measure left ventricle(LV) weight to body weight ratio (Figure 2A), Left atria (LA) to body weight ratio (Figure 2B), Right ventricle (RV) weight to body weight ratio (Figure 2C) and right atria weight to body weight ratio (Figure 2D). Some hearts(n = 5 per condition) were used for measuring cardiomyocyte cross-sectional area (Figure 2E), or for Sirius red staining for fibrosis (Figure 2F) Graphs represent average tissue weights from 8 WT and 8 MACF1 KO mice under control conditions, and 19 WT and 12 MACF1 KO mice under TAC conditions. Cardiomyocyte cross sectional area was averaged from 5 mice (∼300 cells per heart) from each condition (* indicates p<.05 as compared to control conditions, # indicates p<.05 as compared to WT under same conditions).