dKO male mice display attenuated cardiac hypertrophy following TAC.

Male mice were treated with TAC for 8 weeks and their hearts were analyzed. A Representative pictures of control and TAC-operated mice hearts of each genotype. The percentage increase in ventricles weight (VW) to mouse body weight (BW) ratio (mg/gr) by TAC is shown at the bottom. B The ratio of VW/BW is shown (n = 7-15/group). C mRNA was extracted from ventricles and the expression level of cardiac remodeling, hypertrophic and inflammatory markers were measured by qRT-PCR. Expression levels are presented as relative values (compared to wild type control mice, defined as 1, n = 6-8/group). All results represent the mean ± SE ***P ≤ 0.05, control vs. TAC; †P ≤ 0.05, difference between genotypes.