<p>(A, B) Whole-cell current traces and (C, D) summary data for peak current relationships and steady-state inactivation as described for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124921#pone.0124921.g002" target="_blank">Fig 2</a> but for experiments using WT-Q1077 and S1787N/Q1077 (see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124921#pone.0124921.t001" target="_blank">Table 1</a>).</p
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p>V<sub>1/2</sub>, voltage of half-maximal (in)activation; k, slope factor of voltage- dependence o...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>(A) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del ...
<p>(A) and (B) Representative current traces of WT and L233W and Q244W, respectively, recorded as in...
<p>(A) Steady-state activation as function of voltage. (B) Time constants of inactivation as functio...
<p>(<b>a</b>) Representative traces showing whole-cell currents in HEK 293 cells. The upper panel sh...
<p>Steady-state activation (A), time constants of inactivation (B), steady-state inactivation (C) an...
<p>The values of V<sub>50</sub> and k were calculated for each cell, then averaged. R values determi...
<p>(<b>A–E</b>), typical superimposed current traces. The inset illustrates voltage protocol. The bl...
<p><b>A–F</b>, representative ionic currents elicited by whole-cell patch-clamp with the protocol sh...
<p>Summary of electrophysiology parameters for <a href="http://www.plosone.org/article/info:doi/10.1...
c<p>Data from individual activation curves obtained from 5–10 oocytes. Activation curves were fit to...
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>Electrophysiological properties of Kv11.1-wt and Kv11.1-mut channels were assessed using whole-ce...
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p>V<sub>1/2</sub>, voltage of half-maximal (in)activation; k, slope factor of voltage- dependence o...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...
<p>(A) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del ...
<p>(A) and (B) Representative current traces of WT and L233W and Q244W, respectively, recorded as in...
<p>(A) Steady-state activation as function of voltage. (B) Time constants of inactivation as functio...
<p>(<b>a</b>) Representative traces showing whole-cell currents in HEK 293 cells. The upper panel sh...
<p>Steady-state activation (A), time constants of inactivation (B), steady-state inactivation (C) an...
<p>The values of V<sub>50</sub> and k were calculated for each cell, then averaged. R values determi...
<p>(<b>A–E</b>), typical superimposed current traces. The inset illustrates voltage protocol. The bl...
<p><b>A–F</b>, representative ionic currents elicited by whole-cell patch-clamp with the protocol sh...
<p>Summary of electrophysiology parameters for <a href="http://www.plosone.org/article/info:doi/10.1...
c<p>Data from individual activation curves obtained from 5–10 oocytes. Activation curves were fit to...
<p>For the compound outward current in male and female wild-type (KChIP2<sup>+/+</sup>) myocytes the...
<p>Electrophysiological properties of Kv11.1-wt and Kv11.1-mut channels were assessed using whole-ce...
<p>A: Decay from peak of activation during a voltage-clamp of -10 mV in Nav 1.1 modelled channel. Th...
<p>V<sub>1/2</sub>, voltage of half-maximal (in)activation; k, slope factor of voltage- dependence o...
<p>(A) Normalised <i>I</i><sub>Kv6.1</sub> current trace in simulated voltage-clamp experiments. Cur...