Electrophysiological properties of WT-Q1077del and S1787N/Q1077del.

<p>(A) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del recorded for a peak current voltage relationship protocol (diagram inset in panel C) at membrane potentials between -120 to +60 mV in 10-mV increments from a holding potential of -140 mV. (B) Whole-cell current traces from representative experiments of WT-Q1077del and S1787N/Q1077del obtained in response to a steady state inactivation protocol (diagram inset in panel D) test depolarization to 0 mV for 24 ms from a holding potential of -140 mV, following 1s conditioning step to the various conditioning potentials. (C) Summary data for the peak current voltage relationship and (D) steady state inactivation with the line representing a fit to a Boltzmann equation. Parameters of the fits (midpoint V_1/2 and slope K) and n numbers are reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124921#pone.0124921.t001" target="_blank">Table 1</a>.