<p>(A) Distribution of 37 transposable elements (blue), 24 insertion or deletion (indels) targeting a single gene (light green) and 54 point mutations (dark green) scattered across the <i>cps</i> operon. Genes that are missing in one or more capsular types are shown with red font color in the operon diagram. (B) Deletions comprising more than a single gene are indicated with dotted lines; empty spaces represent the absence of <i>cps</i> genes in a specific capsular genotype. (C) Gene targets of capsule inactivation mutations that appeared as single events (blue arrows); the figures below the target genes indicate the number of strains presenting the individual mutation.</p
As we identify more and more genetic changes, either through mutation studies or population screens,...
As we identify more and more genetic changes, either through mutation studies or population screens,...
<p>Protein altering mutations and INDELs, alternative splicing events and validated fusions are show...
<p>(A) Distribution of 126 genetic alteration events detected in 89 isolates. (B) Number of strains ...
<p>(A) Mutations in the <i>cps</i> promoter or <i>cpsA-D</i> detected in 18 NT strains. Their positi...
<p>Blue and green filled rectangles represent lysine biosynthesis genes and those genes that are not...
<p>The <i>cps</i> P1, P2 and P3 promoters are taken from <a href="http://www.plosone.org/article/inf...
A) Locations of point mutations; B) presence of point mutations in the population at the indicated t...
<p>The nucleotide and amino acid changes in the isolates were based on the encapsulated 2603 V/R ref...
<p>A) Plotted on the x-axis is the observed number of coding sequence (CDS) mutations in each of the...
<p>The size of node is proportional to the number of genes in corresponding orthologous gene group, ...
<p>Mutation hotspots which were identified in multiple evolved lines or in the same population more ...
<p>Each <i>cas</i> gene family is indicated with a distinct colour, those specific to a subtype are ...
<p>Schematic of the location of structural variants detected in individual clones compared to the 3D...
Orange boxes correspond to exons, lines to introns. Homology to proteins in the BLOCKS database [38]...
As we identify more and more genetic changes, either through mutation studies or population screens,...
As we identify more and more genetic changes, either through mutation studies or population screens,...
<p>Protein altering mutations and INDELs, alternative splicing events and validated fusions are show...
<p>(A) Distribution of 126 genetic alteration events detected in 89 isolates. (B) Number of strains ...
<p>(A) Mutations in the <i>cps</i> promoter or <i>cpsA-D</i> detected in 18 NT strains. Their positi...
<p>Blue and green filled rectangles represent lysine biosynthesis genes and those genes that are not...
<p>The <i>cps</i> P1, P2 and P3 promoters are taken from <a href="http://www.plosone.org/article/inf...
A) Locations of point mutations; B) presence of point mutations in the population at the indicated t...
<p>The nucleotide and amino acid changes in the isolates were based on the encapsulated 2603 V/R ref...
<p>A) Plotted on the x-axis is the observed number of coding sequence (CDS) mutations in each of the...
<p>The size of node is proportional to the number of genes in corresponding orthologous gene group, ...
<p>Mutation hotspots which were identified in multiple evolved lines or in the same population more ...
<p>Each <i>cas</i> gene family is indicated with a distinct colour, those specific to a subtype are ...
<p>Schematic of the location of structural variants detected in individual clones compared to the 3D...
Orange boxes correspond to exons, lines to introns. Homology to proteins in the BLOCKS database [38]...
As we identify more and more genetic changes, either through mutation studies or population screens,...
As we identify more and more genetic changes, either through mutation studies or population screens,...
<p>Protein altering mutations and INDELs, alternative splicing events and validated fusions are show...