Myriocin improves glucose utilization and insulin sensitivity in LDLR^-/- mice (mean ± SEM, n = 6).

<p>Glucose levels (<b>A</b>) and area under the curve during a glucose tolerance test obtained at 0, 15, 30, 60, and 120 min (<b>B</b>). Glucose levels (<b>C</b>) and area under the curve during the insulin tolerance test was measured at 0, 15, 30, and 60 min post-injection (<b>D</b>). Index of insulin sensitivity (insulin x glucose) in fasted mice (<b>E</b>). Hepatic expression of PI 3-Kinase, Akt and phospho-Akt (serine 473) in LDLR^<b>-/-</b> mice fed a SD, WD, or a WD + myriocin (<b>F</b>). *<i>P</i><0.05, significantly different from all other groups.