Photomicrographs of tissues from CHIKV infected golden Syrian hamsters and control hamsters.

<p>CHIKV infected hamster 5 at 3 DPI had moderate mononuclear fasciitis of the left hind limb (A) associated with vascular endothelium with occasional amphophilic intranuclear inclusion bodies (B). CHIKV infected hamster 6 at 3 DPI had necrotizing and mononuclear myositis and fasciitis of the left hind limb (C) and mononuclear epicarditis (D) with vascular endothelial inclusion bodies (inset). CHIKV infected hamster 9 at 6 DPI had mononuclear tenosynovitis of the left hindlimb (E). CHIKV infected hamster 10 at 6 DPI had severe necrotizing and mononuclear myositis of the left hindlimb (F). Chik V infected hamster 13 at 14 DPI had necrotizing vasculitis of the great vessels and associated myocarditis (G). Distal hind limbs of control hamsters inoculated with PBS and euthanized on 28 DPI had small amounts of histiocytic inflammation and hemosiderin around a blood vessel (H), with no myositis or fasciitis in skeletal muscle (I). Scale bars represent 100 μm (A, D, G) or 400 μm (C, E, F, H, I).