CHIKV infection causes severe myocarditis in mouse neonates.

<p>Histological appearance of horizontal sections of the heart through left and right ventricles of 12-day FVB (<b>A</b>, <b>C</b> and <b>E</b>) and GADD34^ΔC/ΔC mice at D5 pi (<b>B</b>, <b>D</b> and <b>F</b>). Normal appearance of heart of FVB infected mice, at low magnification (<b>A</b>, ×10) with normal cardiomyocytes (<b>C</b>, ×100) and exceptional small foci of lymphocytes (<b>E</b>, ×400). Numerous foci of necrosis in the heart of GADD34^ΔC/ΔC infected mice, at low magnification (<b>B</b>, ×10) and extensive through the ventricular wall (<b>D</b>, ×100). Higher magnification shows few residual cardiomyocytes (arrow head) and inflammation mainly composed of monocytes as well as extensive deposition of calcium (<b>F</b>, ×400). The mice were inoculated with 10⁶ PFU of CHIKV via the intradermal route.