A, Effect of NAC/NACA on MTX-induced PS externalization.

<p>Effect of (<b>B</b>) Dicumarol (<b>C</b>) z-DEVD-fmk and (<b>D</b>) Mito-TEMPO on MTX induced PS externalization on washed platelets. (<b>E</b>) Effect of microparticle-rich fraction on plasma clotting time obtained from MTX-treated platelets. Values are presented as mean ± SEM (n = 5), expressed as percentage increase in (<b>B-D</b>) Annexin V-FITC fluorescence. p*/#< 0.05, p**/##< 0.01, p***/###< 0.001; *: significant compared to control. #: significant compared to MTX.