Effect of MG on platelet adhesion, spreading and <i>in vivo</i> thrombus formation.

<p>(a) Representative pictures and (b) quantification of adherent and spread washed human platelets (to fibronectin (Fn)- or collagen (coll)-coated slides) pre-treated with either solvent (CTL) or methylglyoxal (MG, 1 mmol/L, 15 minutes). (c) Representative pictures (upper panel) and quantification (lower graphs) of the effect of <i>in </i><i>vivo</i> treatment of healthy mice with MG (1 mmol/L, 15 minutes) on thrombus size and time to peak after FeCl₃-induced injury of carotid artery. The graphs summarize data obtained in platelets from 12 subjects or 6 animals per group; *P<0.05, ***P<0.001, versus CTL.