<p>A. Bar graph of averaged binding ratios of 3 independent screenings. Error bar indicates the standard deviation (n = 3). The red line indicates the average binding ratio obtained after addition of DMSO and GTP (= 0.411). The white arrow indicates the chemical that most effectively inhibited FtsZ dimerization. B. The Venn diagram shows a summary of the 2nd screening results.</p
<p>The picture illustrates the flow and the results of screening re-profiling of the over 1,200 clin...
The “RIKEN” screen consisted of 8418 total compounds from the RIKEN Natural Product Depository, and ...
<p>Bars represent the mean intensity value from three individual samples, with standard deviation in...
<p>A. Bar graph of averaged binding ratios from 3 independent screenings. Error bar indicates the st...
<p>A. When a chemical has an inhibitory effect on FtsZ dimerization even in the presence of GTP, the...
<p>(A) Compounds screened ranked by percent inhibition and normalized to negative and positive contr...
<p>The chemicals are numbered from #1 to #6 in order of the inhibition % calculated from FCCS analys...
<p>All hit compounds identified were chemical clustered using pubchem finger prints. (A) The major c...
<p>Scatter plot of screening data for a small library of known bioactive small molecules using the P...
<p>A) Alterations in cell number A) after 24 (open squares) or 48 hours exposure (closed triangles) ...
<p>Compounds with >40% activity against either <i>Ldon</i> [red], <i>Pfal</i> [yellow] or both NMT t...
<p>(A) Layout of microplate. Wells marked in green are CXCR4 inhibitors. Controls are shown in white...
<p>One PPARγ full agonist (Rosiglitazone) and one partial agonist (FMOC) were also assayed. Error ba...
<p>The chart represents the averaged inhibitory percentage with error bars representing standard dev...
<p>Merged images for nucleus, PV and amastigote fluorescence of one acquisition field representing d...
<p>The picture illustrates the flow and the results of screening re-profiling of the over 1,200 clin...
The “RIKEN” screen consisted of 8418 total compounds from the RIKEN Natural Product Depository, and ...
<p>Bars represent the mean intensity value from three individual samples, with standard deviation in...
<p>A. Bar graph of averaged binding ratios from 3 independent screenings. Error bar indicates the st...
<p>A. When a chemical has an inhibitory effect on FtsZ dimerization even in the presence of GTP, the...
<p>(A) Compounds screened ranked by percent inhibition and normalized to negative and positive contr...
<p>The chemicals are numbered from #1 to #6 in order of the inhibition % calculated from FCCS analys...
<p>All hit compounds identified were chemical clustered using pubchem finger prints. (A) The major c...
<p>Scatter plot of screening data for a small library of known bioactive small molecules using the P...
<p>A) Alterations in cell number A) after 24 (open squares) or 48 hours exposure (closed triangles) ...
<p>Compounds with >40% activity against either <i>Ldon</i> [red], <i>Pfal</i> [yellow] or both NMT t...
<p>(A) Layout of microplate. Wells marked in green are CXCR4 inhibitors. Controls are shown in white...
<p>One PPARγ full agonist (Rosiglitazone) and one partial agonist (FMOC) were also assayed. Error ba...
<p>The chart represents the averaged inhibitory percentage with error bars representing standard dev...
<p>Merged images for nucleus, PV and amastigote fluorescence of one acquisition field representing d...
<p>The picture illustrates the flow and the results of screening re-profiling of the over 1,200 clin...
The “RIKEN” screen consisted of 8418 total compounds from the RIKEN Natural Product Depository, and ...
<p>Bars represent the mean intensity value from three individual samples, with standard deviation in...