PGC-1α facilitates lysosomal degradation of POS in ARPE-19 cells.

<p><b>(A)</b> In cells transfected with PGC-1α siRNA, Oil Red O staining after POS treatment was more intense than those transfected with control siRNA. Scale bar, 200 μm. <b>(B)</b> In cells transfected with PGC-1α siRNA, the accumulation of peroxidized lipids evaluated by BODIPY C11 fluorescence increased after POS treatment compared to those transfected with control siRNA. Mean ± SEM, n = 6 per group, ANOVA and Tukey’s test, *<i>P</i> < 0.05.