Gefitinib and erlotinib suppressed growth of A549 cells in a concentration-dependent manner.

<p>The effects of (A) gefitinib and (B) erlotinib (1–10 μM) on cell proliferation of A549 cells were investigated. Cell counts were estimated by the MTT assay. Data are expressed as means ± S.E.M. of three independent experiments. Each symbol indicates significant differences from DMSO group; a, <i>p</i> < 0.05; aa, <i>p</i> < 0.01 (DMSO vs. 1 μM), bb, <i>p</i> < 0.01; bbb, <i>p</i> < 0.001 (DMSO vs. 5 μM), c, <i>p</i> < 0.05; cc, <i>p</i> < 0.01; ccc, <i>p</i> < 0.001 (DMSO vs. 10 μM), one-way ANOVA with Dunnett’s post hoc tests.