Anti-MMP-2 antibody therapy in MMP-9 null mice.

<p>The serum AST levels (panel A) in MMP-9^-/- mice treated with anti-MMP-2 antibodies at 6h of liver IRI were significantly reduced when compared to wild-type mice treated with anti-MMP-2 antibodies and increased when compared to MMP-9^-/- mice treated with IgG. Histological preservation (panel B) was markedly improved in MMP-9 null livers treated with MMP-2 mAb at 6h after IRI (b), when compared to the extensively damaged anti-MMP-2 mAb treated WT livers (a), but inferior when compared to MMP-9^-/- livers treated with control IgG (c) (n = 4/group; *p<0.05 relative to WT+MMP-2mAb; **p<0.05 relative to MMP-9^-/-+IgG).