<p>Mean serum concentrations (± SD) from individual mice receiving standard TB treatment in combination with anti-MMP-9 (AB0046, red circle) or isotype control (AB5123, black circle) are depicted. Mice were sacrificed at week 2 (n = 13) and 6 (n = 13) during the dosing phase, and at week 8 (n = 13), 10 (n = 7), and 12 (n = 7) during the antibody elimination phase.</p
<p>(<b>A</b>) Spleens from TB and control. mice. (<b>B</b>) Weights of spleens from TB and control m...
<p>SJL mice were immunized with p139 in IFA containing or not 50 or 200 microgrammes/mouse of <i>M t...
Pharmacokinetic evaluation of peripheral and brain antibody level following intravenous injection of...
Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune responses...
<div><p>Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune r...
<p>(<b>A</b>) MDSC percentages in peripheral blood (PB) from TB and control mice. Shown are represen...
<p>Mouse anti-humane-IgG IgG was used as positive control and BSA were used as negative control.</p
<p>Log<sub>10</sub> reduction provided by compound <b>9a</b> in lungs (black bars) and spleen (grey ...
<p>Splenic recall assays were performed to monitor the immune responses during TB treatment in anima...
Recently we proposed exploring the potential of treatment stimulated testing as diagnostic method fo...
Background: The only available tuberculosis (TB) vaccine, Bacillus Calmette-Guérin (BCG), has variab...
<p>IFNγ, IP-10, MIG and MCP-1 levels were measured in infected (left hand panels, A, C, E, G) and no...
<p>Serum concentration profiles (mean ± SD) for IL-2 and IL-10 cytokines in weeks 18 and 22 from <i>...
To evaluate novel approaches for tuberculosis (TB) diagnostics and treatment, well-validated animal ...
Recently we proposed exploring the potential of treatment stimulated testing as diagnostic method fo...
<p>(<b>A</b>) Spleens from TB and control. mice. (<b>B</b>) Weights of spleens from TB and control m...
<p>SJL mice were immunized with p139 in IFA containing or not 50 or 200 microgrammes/mouse of <i>M t...
Pharmacokinetic evaluation of peripheral and brain antibody level following intravenous injection of...
Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune responses...
<div><p>Matrix metalloproteinase (MMP)-9 is a zinc-dependent protease associated with early immune r...
<p>(<b>A</b>) MDSC percentages in peripheral blood (PB) from TB and control mice. Shown are represen...
<p>Mouse anti-humane-IgG IgG was used as positive control and BSA were used as negative control.</p
<p>Log<sub>10</sub> reduction provided by compound <b>9a</b> in lungs (black bars) and spleen (grey ...
<p>Splenic recall assays were performed to monitor the immune responses during TB treatment in anima...
Recently we proposed exploring the potential of treatment stimulated testing as diagnostic method fo...
Background: The only available tuberculosis (TB) vaccine, Bacillus Calmette-Guérin (BCG), has variab...
<p>IFNγ, IP-10, MIG and MCP-1 levels were measured in infected (left hand panels, A, C, E, G) and no...
<p>Serum concentration profiles (mean ± SD) for IL-2 and IL-10 cytokines in weeks 18 and 22 from <i>...
To evaluate novel approaches for tuberculosis (TB) diagnostics and treatment, well-validated animal ...
Recently we proposed exploring the potential of treatment stimulated testing as diagnostic method fo...
<p>(<b>A</b>) Spleens from TB and control. mice. (<b>B</b>) Weights of spleens from TB and control m...
<p>SJL mice were immunized with p139 in IFA containing or not 50 or 200 microgrammes/mouse of <i>M t...
Pharmacokinetic evaluation of peripheral and brain antibody level following intravenous injection of...