Effect of PJ34 (PARP inhibitor) administration in hepatic IRI.

<p>Administration of PJ34 to wild-type mice and to MMP-2^-/- mice at reperfusion reduced the serum AST levels (panel A) in these mice at 6h post-IRI. MMP-2^-/- mice treated with PJ34 showed improved liver histological preservation (panel B) post-IRI; H&E staining of vehicle treated-MMP-2^-/- (a) and PJ34 treated-MMP-2^-/- (b) livers post-reperfusion. MMP-9 activity was significantly depressed in MMP-2 null mice treated with PJ34 at 6h after IRI (n = 4–5/group; *p<0.05).