Granuloma scores.

<p>The granuloma scores were obtained by counting the numbers of granulomata individually at 100 × magnification. Each data point represented average number of granulomata from 10 microscopic fields from H&E stained lung section from one mouse. A: The granuloma scores in the pigeon dropping extract(PDE)-challenged mice. The scores on days 7 and 10 were significantly increased compared with days 0 and 2. B: The granuloma scores on day 10 in the saline-treated mice and the PDE-challenged mice, with and without interleukin(IL)-17A antibody-administration. The score in the PDE-challenged mice was significantly increased compared with that of the saline-treated mice (<i>P</i> < 0.001), and the score in the PDE-challenged mice subjected to anti-IL-17A antibody administration was significantly decreased compared with the PDE-challenged mice (<i>P</i> = 0.021). The data are presented as the means ± standard errors of the mean (SEs) for each group (day 0–10: n = 7–11, control group: n = 10, PDE group: n = 11, anti-IL-17A group: n = 8). *: <i>P</i> < 0.05, **: <i>P</i> < 0.01, ***: <i>P</i> < 0.001.