Characterization of the six-way genetic interaction.

<p>(<b>A</b>) Allele frequency plots for BY and 3S second iteration backcross populations of <i>END3</i>^<i>3S</i> rough strains. Fixed loci are denoted with a blue, orange, or grey bars depending on whether the BY, 3S, or mutant alleles, respectively, were detected at a locus. The allele frequencies were estimated by averaging data in sliding windows containing 10 SNPs. (<b>B</b>) Cryptic variants involved in the five- and six-way interactions. (<b>C</b>) Dependence of both genetic interactions on the <i>ira2Δ</i>2933 mutation.