Enhancement of uridine-induced neurite outgrowth is (a) ERK-, (b) Akt-, (c) MEK- & mTOR-, and (d) CREB-dependent as evidenced by the expression of phospho-ERK1/2 (p44/p42), Akt (Thr308), MEK (Ser217/221) & mTOR (Ser2448), and CREB (Ser133) as detected using specific antibodies.

<p>U0126 and PD98059 are the inhibitors for ERK. LY294002 is the inhibitor for PI3K/Akt. Data are expressed as mean ± S.D. for n = 3. Different alphabets represent significant differences between samples (<i>p</i> < 0.05). *<i>p</i> < 0.05 significantly lower relative to group without inhibitor treatment. ^#<i>p</i> < 0.05 significantly higher relative to NGF.