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Hypothetic mechanism of uridine in promoting neurite outgrowth in N2a cells.

  • Chia-Wei Phan (807851)
  • Pamela David (807852)
  • Kah-Hui Wong (807854)
  • Murali Naidu (807853)
  • Vikineswary Sabaratnam (603072)
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Publication date
November 2015
Icon DOI
10.1371/journal.pone.0143004.g008

Abstract

<p>Uridine could induce neurite outgrowth associated with expression of neuronal differentiation marker (GAP-43, tubA4a, and tubB1). Uridine stimulated CREB phosphorylation and neurite outgrowth mainly through activation of P2Y-dependent pathway. MEK/ERK1/2 and PI3K/Akt/mTOR were also partly involved in the uridine-induced neurite outgrowth. ↑ = increase.</p

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