Hepatocyte apoE modulates liver steatosis and hepatic inflammation.

<p>(A) Total liver triglyceride and (B) cholesterol measurement of <i>Apoe</i>^ΔHep and <i>Apoe</i>^ΔAT mice 16 weeks after feeding a chow, HFD or WTD diet. Apoe^ΔHep and respective controls on chow (n≥5), HFD (n≥5) and WTD (n≥6); Apoe^ΔAT and respective controls on chow (n≥5), HFD (n≥6) and WTD (n≥3). Haematoxylin-Eosin stained liver sections of (C-E) WT controls or (F-H) <i>Apoe</i>^ΔHep on (C,F) chow, (D,G) HFD or(E,H) WTD. Scale bar: 50μm. (I) Plasma ALT activity of control and <i>Apoe</i>^ΔHep mice on HFD or WTD. (J-L) Oral glucose tolerance test of <i>Apoe</i>^ΔHep mice on either (J) chow, (K) HFD or (L) WTD. (M-P) Liver gene expression of (M) <i>Tnf</i>, (N) <i>Cd68</i>, (O) <i>Cxcl-2</i> and (P) <i>Cxcl-10</i>. I, M-P: Apoe^ΔHep and respective controls on chow (n≥4), HFD (n≥5) and WTD (n≥4). J, K, L: Apoe^ΔHep and respective controls on chow (n≥5), HFD (n≥8) and WTD (n≥6). WT: Wild type mice. HFD: high fat diet. WTD: Western type diet. Mean values ± s.e.m. Statistical analysis with <i>Students T-Test</i>. *: p<0.05.