Hepatic apoE regulates VLDL production and lipoprotein uptake.

<p>(A-D) VLDL production after tylaxopol injection in <i>Apoe</i>^ΔHep mice on (A,B) chow or (C,D) Western type diet. Apoe^ΔHep and respective controls on chow (n≥8) and WTD (n≥7). (E,F) Plasma apoE profile by FPLC and apoE-ELISA on (E) chow or (F) Western type diet. (G,H) ApoE-free ¹²⁵I-VLDL turnover in <i>Apoe</i>^ΔHep mice with (G) plasma decay and (H) organ distribution (n≥5). WT: Wild type mice. WTD: Western type diet. Mean values ± s.e.m. Statistical analysis with <i>Students T-Test.</i> *: p<0.05.