Loss of hepatic apoE leads to dyslipidemia on Western type diet.

<p>(A) Total plasma cholesterol (B) or triglyceride level in <i>Apoe</i>^ΔHep and <i>Apoe</i>^ΔAT mice on chow, HFD and WTD. Apoe^ΔHep and respective controls on chow (n≥8), HFD (n≥6) and WTD (n≥6). Apoe^ΔAT and respective controls on chow (n≥7), HFD (n≥8) and WTD (n≥3). (C-E) FPLC profiles of pooled samples for cholesterol in <i>Apoe</i>^ΔHep mice or (F-H) in <i>Apoe</i>^ΔAT mice on (C,F) chow, (D,G) HFD or(E,H) WTD. WT: Wild type mice. HFD: high fat diet. WTD: Western type diet. Mean values ± s.e.m. Statistical analysis with <i>Students T-Test.</i> *: p<0.05.