<p>A) Immunostaining of pancreatic tissue from 12 m old mice for Ki-67 (top, green) and TUNEL (bottom, green). β-cells are demarcated by insulin (red) and nuclei are counterstained with DAPI. Scale bar denotes 50 μM. B) Quantification of proliferating cells by Ki-67 staining. C) Quantification of apoptotic cells by TUNEL. No comparisons are significant. Number of mice in each group as indicated.</p
<p>Immunohistochemical staining of Ki-67 of whole pancreata was performed from T1DM mice after treat...
<p>Whilst no apoptosis was identified in islets from LFD controls (A), TUNEL-positive cells were fou...
<p><b>A</b>) Proliferation was assessed via immunohistochemistry for proliferating cell nuclear anti...
<p>A) Body weights (both genders). B) Fasting plasma insulin concentrations (both genders). C) Fasti...
<p>A) Endocrine (Endo) and exocrine (Exo) pancreatic tissue from 12 m old mice before (top) and afte...
<p>(A–F) Quantification of pancreatic islets area and islets density at the indicated age in wild-ty...
<p>A Representative islets showing insulin (red) and Ki67 (green, indicated by arrows), insulin (red...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
<p>Mice at the indicated ages were killed and apoptosis of insulin-expressing cells on islet section...
<p>Pancreatic sections of 3 and 12-month-old mice at the indicated time points after initiation of c...
<p>Six female mice per genotype and per age were used (one section per animal). The results are repr...
<p>(<b>a</b>) Quantification of proliferating beta cells. Photographs are representative images of i...
<p>(A) The TUNEL positive cells were marked with dark brown in nucleis, and the sections were staine...
<p><b>(a-d)</b> Staining for insulin (yellow) and <b>(a-b)</b> Ki67 (green) or <b>(c-d)</b> EdU (red...
<p>A) Enhanced caspase-3 activity is detected in cell extracts of WT than in those of CD44-deficient...
<p>Immunohistochemical staining of Ki-67 of whole pancreata was performed from T1DM mice after treat...
<p>Whilst no apoptosis was identified in islets from LFD controls (A), TUNEL-positive cells were fou...
<p><b>A</b>) Proliferation was assessed via immunohistochemistry for proliferating cell nuclear anti...
<p>A) Body weights (both genders). B) Fasting plasma insulin concentrations (both genders). C) Fasti...
<p>A) Endocrine (Endo) and exocrine (Exo) pancreatic tissue from 12 m old mice before (top) and afte...
<p>(A–F) Quantification of pancreatic islets area and islets density at the indicated age in wild-ty...
<p>A Representative islets showing insulin (red) and Ki67 (green, indicated by arrows), insulin (red...
(A) Representative immunofluorescent images of islets by cleaved caspase-3 (red), β-cell marker insu...
<p>Mice at the indicated ages were killed and apoptosis of insulin-expressing cells on islet section...
<p>Pancreatic sections of 3 and 12-month-old mice at the indicated time points after initiation of c...
<p>Six female mice per genotype and per age were used (one section per animal). The results are repr...
<p>(<b>a</b>) Quantification of proliferating beta cells. Photographs are representative images of i...
<p>(A) The TUNEL positive cells were marked with dark brown in nucleis, and the sections were staine...
<p><b>(a-d)</b> Staining for insulin (yellow) and <b>(a-b)</b> Ki67 (green) or <b>(c-d)</b> EdU (red...
<p>A) Enhanced caspase-3 activity is detected in cell extracts of WT than in those of CD44-deficient...
<p>Immunohistochemical staining of Ki-67 of whole pancreata was performed from T1DM mice after treat...
<p>Whilst no apoptosis was identified in islets from LFD controls (A), TUNEL-positive cells were fou...
<p><b>A</b>) Proliferation was assessed via immunohistochemistry for proliferating cell nuclear anti...