The <i>RIM101</i> allele achieves remarkable specificity, but genetic background controls its regulatory capacity.

<p>(A) Scatter plots displaying expression levels for each gene (dots) in <i>RIM101</i> interconverted strains relative to their respective wildtype strains (Red = <i>RIM101</i>-dependent genes as defined in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005746#pgen.1005746.g004" target="_blank">Fig 4</a>). (B) Scatter plot displaying levels of each gene in Σ1278b relative to S288c wildtype strains (Red = <i>RIM101</i>-dependent genes). (C) Scatter plot displaying expression levels in the <i>RIM101</i>-interconverted strain, S288c(Σ<i>RIM101</i>) relative to Σ1278b wildtype (Red = <i>RIM101</i>-dependent genes). (D) Scatter plot displaying expression levels in S288c <i>rim101Δ</i> relative to Σ1278b wildtype (Red = <i>RIM101</i>-dependent genes). (E) Cumulative distribution function (CDF) plot showing the results of linear regression analysis of the distance of the 822 <i>RIM101</i>-dependent genes from a line of best fit for each strain comparison (Colored lines correspond to comparisons defined in legend). (F) Scatter plot displaying expression levels in Σ1278b(S2<i>RIM101</i>) relative to S288c wildtype (Red = <i>RIM101</i>-dependent genes). (G) Scatter plot displaying expression levels in Σ1278b <i>rim101Δ</i> relative to S288c wildtype (Red = <i>RIM101</i>-dependent genes).