Rim101-dependent gene regulation during invasive infection.

<p>RNA levels for 148 <i>C</i>. <i>albicans</i> environmental response genes were determined by nanoString at 24 hr postinfection for the <i>rim101</i> mutant and complemented strains (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.s005" target="_blank">S5 Data</a>). (A). Expression ratios are plotted for each gene in <i>rim101Δ/Δ</i> versus wild type (X axis) and <i>rim101Δ/Δ</i> versus complemented strain (Y axis). Three genes (red data points) have significantly different expression ratios in the two comparisons. (B). Expression ratios are presented for all genes significantly down-regulated in the <i>rim101Δ/Δ</i> strain relative to the complemented strain during kidney infection (blue bars; ≥2-fold change and <i>p</i>-value < 0.05). The expression ratios for the same genes in the same strains during intra-abdominal candidiasis (IAC) infection (red bars; reported in [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.ref012" target="_blank">12</a>]) or during in vitro growth in Spider medium (green bars) are displayed. Complete data are in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.s005" target="_blank">S5 Data</a>. (C). Expression ratios are presented for all genes significantly up-regulated in the <i>rim101Δ/Δ</i> strain relative to the complemented strain during kidney infection (blue bars; ≥2-fold change and <i>p</i>-value < 0.05), during abdominal infection (red bars; reported in [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.ref012" target="_blank">12</a>]) or during in vitro growth in Spider medium (green bars) are displayed. Complete data are in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.s005" target="_blank">S5 Data</a>. All numerical data for this figure are in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002076#pbio.1002076.s007" target="_blank">S7 Data</a>.