IL-17 axis deficiency augments hepatic steatosis, but protects from hepatocellular damage.

<p>8 week old male IL-17RA^-/-, IL-17A^-/-, and IL-17F^-/- mice on a C57BL/6 background and WT controls (<i>n</i> = 4-8/condition) were placed on MCDD or chow diet for 4 weeks. (<b>A</b>) Hepatic triglyceride levels. (<b>B</b>) Hepatic SCD-1 mRNA expression. (<b>C</b>) Serum alanine transaminase (ALT) levels. AU = Arbitrary units, as compared to beta actin. Data represent means + SE; a representative of two separate experiments. Student <i>t</i> test *<i>P</i> < 0.05, ** <i>P</i> < 0.01, *** <i>P</i> < 0.001.