Number of HGSOC carcinogenetic events leading to HGSOC growth and progression.

<p>In one representative simulation of the model generating 1000 cancer-positive initially clinically occult HGSOC growth curves, (A) 491 sample HGSOC growth curves progress to reach the detectability threshold and (B) 418 reach the life-threatening volume threshold. (A) We record the frequency of rate-limiting events associated with changes in the initial growth saturation rate, k_decay out of the <i>n = 491</i> growth curves. For this representative simulation, the mode and median number of such events are 5, and 7 respectively. (B) We record the number of rate-limiting events associated with changes in the initial growth saturation rate, k_decay, out of <i>n = 418</i> growth curves. For this representative simulation, the mode and median of the number of such events are 7, and 7 respectively. A maximum number of 10 events associated with changes in the initial growth saturation rate, k_decay, is recorded in both panels.