<p>(A) Simulation with one malignant cell (increased proliferation rate <i>p</i>) initiated in the third month. The clone in which the mutation occurs is depicted in grey. (B) The average time until clonal dominance beginning at the time point of cancer initiation.</p
Carcinogenesis is the result of mutations and subsequent clonal expansions of mutated, selectively a...
<p><b>B)</b> Simulation snapshots of the smallest, an average-sized and biggest tumor in the control...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
<p>Multistage clonal expansion models are continuous-time Markov chain models in which normal cells ...
Multistep carcinogenesis through sequential cycles of mutation and clonal succession is usually desc...
<p>The graph shows the evolution through time iterations of the number of Differentiated Cancer Cell...
<p>The graph shows the evolution through time iterations of the number of Differentiated Cancer Cell...
Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. Th...
<p>(a) During each cell division, a mutation might arise which changes the fitness of a daughter cel...
<p>Variation of the cumulative clone density in time for the cases: simulation with , simulation...
As a cancer develops, its cells accrue new mutations, resulting in a heterogeneous, complex genomic ...
<div><p>Tumors consist of a hierarchical population of cells that differ in their phenotype and geno...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
<p>Normal squamous epithelium may transform to BE with an exponentially distributed onset time with ...
Cancer is a disease of somatic evolution. Random mutations that arise during life and confer a growt...
Carcinogenesis is the result of mutations and subsequent clonal expansions of mutated, selectively a...
<p><b>B)</b> Simulation snapshots of the smallest, an average-sized and biggest tumor in the control...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
<p>Multistage clonal expansion models are continuous-time Markov chain models in which normal cells ...
Multistep carcinogenesis through sequential cycles of mutation and clonal succession is usually desc...
<p>The graph shows the evolution through time iterations of the number of Differentiated Cancer Cell...
<p>The graph shows the evolution through time iterations of the number of Differentiated Cancer Cell...
Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. Th...
<p>(a) During each cell division, a mutation might arise which changes the fitness of a daughter cel...
<p>Variation of the cumulative clone density in time for the cases: simulation with , simulation...
As a cancer develops, its cells accrue new mutations, resulting in a heterogeneous, complex genomic ...
<div><p>Tumors consist of a hierarchical population of cells that differ in their phenotype and geno...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
<p>Normal squamous epithelium may transform to BE with an exponentially distributed onset time with ...
Cancer is a disease of somatic evolution. Random mutations that arise during life and confer a growt...
Carcinogenesis is the result of mutations and subsequent clonal expansions of mutated, selectively a...
<p><b>B)</b> Simulation snapshots of the smallest, an average-sized and biggest tumor in the control...
Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics ...
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